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21st Century Audiology: Hair Cell Regeneration, presented in partnership with Salus University

View Course Details Please note: exam questions are subject to change.


1.  ____________ signaling is critical during development to allow precursor cells to differentiate.
  1. Jag 1
  2. Sox 2
  3. Notch
  4. p27kip1
2.  ____________ is both necessary and sufficient as a genetic signal for precursor cells to differentiate into hair cells.
  1. Notch
  2. Hes 5
  3. FGF
  4. Atoh 1
3.  We’ve learned from birds that hair cell regeneration/replacement occurs through two mechanisms: mitosis and ___________.
  1. Transdifferentiation/conversion
  2. Stem cell division
  3. Pillar cell division
  4. Over expression of p27kip1
4.  Investigators have used _______ cells to form auditory neurons as well as hair cells in a dish:
  1. Embryonic stem cells (eSC)
  2. Pre-cancerous stem cells (pSCC)
  3. Induced pluripotent stem cells (iPS)
  4. Both A & C
5.  At this time, stem cells seem most likely to be successful at replacing/regenerating:
  1. Pillar cells
  2. Neurons
  3. Hair cells
  4. Supporting cells
6.  What kind of genetic signaling would help restore hair cells to the damaged cochlea?
  1. Notch/delta
  2. Wnt
  3. Atoh 1
  4. All of the above
7.  Successful hair cell regeneration/restoration using gene therapy was first reported in ___________.
  1. 1988
  2. 2003
  3. 2005
  4. No successful reports to date
8.  Small molecule therapy using inhibition of _______ signaling has shown some success in restoring hearing in mice:
  1. Sox
  2. Atoh 1
  3. Notch
  4. Lgr5
9.  There are currently ________ registered clinical trials directly investigating the potential for hair cell regeneration/restoration in humans:
  1. 0
  2. 1
  3. 3
  4. 10
10.  In the future Audiologists will be involved with biological and pharmaceutical therapy to:
  1. Determine candidacy
  2. Quantify therapeutic success
  3. Counsel patients
  4. All of the above

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